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See your doctor right away if you have any of the following: A sore that bleeds easily and does not heal A lump or thickening in your mouth or neck Soreness or swelling that does not go away A red or white patch that does not go away Trouble chewing, swallowing, or moving your tongue or jaw If you use smokeless tobacco, your doctor and dentist should carefully examine your mouth at each checkup

It may also inform policy development and ongoing epidemiological research

Materials and methods Study design In three separate randomized, open-label, crossover, in-clinic confinement studies, subjective effects and nicotine uptake of Velo ONPs were evaluated among adult smokers

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