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Mail-order pharmacies say that their packaging is weather resistant and that they take special precautions when medication requires specific temperature control. But in a study published last year, independent pharmaceutical researchers who embedded data-logging thermometers inside simulated shipments found that the packages had spent more than two-thirds of their transit time outside the appropriate temperature range, regardless of the shipping method, carrier, or season. Extreme temperatures can alter the components in many medications, from pancreatic enzymes to the thyroid replacement drug levothyroxine to oral contraceptives, medical experts say