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With respect to the recently described two major pulmonary DC subsets, it appears that allergic airway inflammation primarily expands the CD11b-high/CD103-negative DC subpopulation, which is a powerful producer of inflammatory chemokines

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"These findings highlight a large gap in our understanding of how continued tobacco use might influence drug metabolism, therapeutic response and long-term outcomes," the experts said, adding that the issue is most pressing in low and middle-income countries with 80 per cent of tobacco users