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Mendelian randomisation (MR) analysis In the present study, a modified Mendelian randomisation approach was performed to investigate a potential causal relationship 36,65 , in which non-pleiotropic polygenic risk scores (i.e., the valid-PRS) were established as instrument variables of randomised experiments for potential causal inference

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Based on these findings, numerous public health bodies including the UK Royal College of Physicians, the US Surgeon General and the International Agency for Research on Cancer have concluded that smoking is causally associated with numerous diseases [6, 15, 16]

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