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Statistical analysis Cox proportional hazards models were used to examine the associations between cigar status and mortality outcomes based on underlying causes of death from the 10th revision of International Statistical Classification of Diseases and Related Health Problems (ICD-10) [21], reported as hazard ratios (HRs, with 95% confidence intervals, CI) with never smokers as the referent group

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Apart from urban and rural categories, the 31 provinces (or equivalent) in China were grouped into 7 major geographic regions to assess regional differences in smoking prevalence and patterns ( Appendix C in S1 Text )

Department of Health and Human Services, National Institutes of Health, National Cancer Institute