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Marketing authorization may be acquired using one of the following pathways (21 USC 387j): Substantial equivalence (SE) report for new TNCPs that have the same characteristics as another product with market approval or its exemption when applicable Premarket Tobacco Product Application (PMTA) The information to be included into SE reports is judged on a case-by-case basis, primarily depending on the changes proposed to the new product compared to a predicate product in a report

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Create regional and country strategies on the basis of local data and analysis

Over the last ten years, we've seen some of the industry's biggest stars (Leonardo DiCaprio, Emma Stone, Brad Pitt, Kristen Stewart, Cate Blanchett) puff away in front of the camera