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So Selye began to suggest that subjecting an animal to prolonged stress led to tissue changes and physiological changes with the release of certain hormones, that would then cause disease and ultimately the death of the animal." And so the idea of stress and its potential costs to the body was born

Buydens recounted this meeting with her future husband in their book, Kirk and Anne: Letters of Love, Laughter, and a Lifetime in Hollywood , a compilation of letters the couple sent to each other during their courtship and marriage