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Independent research found e-cigarette packaging nationwide is often misleading or even completely inaccurate on the products nicotine level.[2] Sometimes e-cigarette packages claim the device contains no nicotine, but when tested the product in fact contained high levels of the addictive and harmful substance.[3] Some studies compared JUUL pods to a pack of cigarettes, and the claim one pod was roughly equivalent to one pack of cigarettes.[4] However, the studies found the amount of nicotine varied dramatically from pod to pod, making any comparison loose at best.[5] JUULs popularity has decreased over the past several years, with brands like Vuse and Puff Bar increasing in sales, each with their own formulations.[6] An early e-cigarette study published in Nicotine & Tobacco Research compared different e-cigarette brands for 15 puffs and saw nicotine levels varying from 0.5 milligrams all the way up to 15.4 milligrams.[7] Newer e-cigarettes may also contain much larger e-liquid reserves, further clouding the calculations

Abbreviations ANOVA: Analysis of variance KDE: Kernel density estimation GIS: Geographical information systems SIMD: Scottish index of multiple deprivation References World Health Organisation

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Harmine also reduced the expression of Mcl-1 and made the non-small cell lung cancer cells more sensitive to inhibitors of Bcl-2 because, in NSCLC, the expression of Mcl-1 results in acquired resistance to the inhibitors of Bcl-2