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As a result of optimizing cond itions of life and functioning of the fibroblasts and tissue leukocytes the metabolism of extracellular matrix components of the connective tissue of the dermis intensifies, there is a re- juvenation of collagen and elastin fibers, which is mani- fested in the appearance of finer structures and ordering their location [13]

Kaestner R, Schiman C, Ward J

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Non-invasive approaches include the detection of biological markers such as enzymes, antibodies, or specific proteins (e.g., lactoferrin, calprotectin, and C-reactive protein in bodily fluids that can be collected non-invasively, such as urine, fecal matter, or saliva (Hickman, 2024