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Early diagnosis remains difficult, but a suite of advanced non-invasive modalitiesincluding impulse oscillometry system/forced oscillation techniques (IOS/FOT), single- and multiple-breath washout tests, high-resolution CT with parametric response mapping (PRM), nuclear medicine approaches (e.g., SPECT), dynamic measurements of lung compliance, and Fluorine-19 ( 19 F) MRIcombined with artificial intelligence markedly improve the sensitivity and specificity for detecting small-airway disease

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