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A 1.66-fold increase in CYP1A2 activity was observed for smokers consuming 1120 cigarettes daily (Tantcheva-Por et al., 1999)

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Humans Earliest Evidence of Tobacco Use Uncovered in Utah The charred seeds suggest that people used tobacco over 12,000 years agomuch earlier than previously thought Within the mudflats of the Great Salt Lake Desert in Utah, archeologists uncovered four 12,300-year-old charred tobacco seeds in an ancient hearth once used by hunter-gatherers near the end of the Pleistocene Epoch, reports Charles Q

Clicks when its ready: Eliminate the guesswork of manual heating