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The gum contains butylhydroxytoluene (E321) which may cause local irritation of the oral mucosa

Additionally, there may be a decline in glucose and lipid metabolism, and weight gain can often lead individuals to resume smoking

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Conclusion: Thus, we may conclude that addiction to nicotine in peptic ulcers causes an increase of offensive factors and a decrease of defensive factors, and in gastrointestinal cancers, causes an increase in angiogenesis, metastasis, and proliferation and decrease in apoptosis in ulcerative colitis