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Although the estimated caffeine exposures from e-cigarettes are at levels significantly lower than those from drinking caffeinated beverages, very little is known about the effects of caffeine inhalation, and health risks cannot be estimated

The pathogenesis involves nicotine/acetylcholine-induced follicular occlusion, follicular rupture, and immune dysregulation

In the meantime, I would tell smokers who want to quit or cut down to use one of the FDA-approved smoking cessation medications, which are known to be safe and effective, as a first choice

Accessibility to the contents is facilitated by either the flip-top design for ease or the slide-and-shell design for added safety