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PMC 6353171

The researchers found that the public interpreted the messages, and specifically the presentation of the risk of having a heart attack, within their own framework

Tobacco and FDA Regulation

This is consistent with reports that GSK3 promotes NRF2 degradation, whereas AKT-mediated phosphorylation of GSK3 inhibits this process, thereby stabilizing NRF2 and enhancing its nuclear localization 11,20,26,28