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As such, one plausible mechanistic account is that repeated stimulation of high densities of nAChRs by nicotine may contribute to neurotoxicity within discrete regions and/or increase the vulnerability of those regions to other volatile compounds in tobacco smoke [19] which ultimately manifest as gray matter decreases

Cigarette packs are being stripped of advertising around the world

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Beginner-friendly options like prefilled pod systems, cigalikes, or starter kits with high-nicotine e-liquids (like 18mg or nicotine salts) are ideal