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Results Increased glucose uptake in cigarette smoking-associated EGFR TKI resistance in NSCLC To address the mechanism underlying cigarette smoke-triggered EGFR TKI resistance in EGFR WT NSCLC, H292 NSCLC cells, which express EGFR WT and are sensitive to EGFR TKI, were subjected to long-term treatments with CSE or benzo[]pyrene (B[]P), a human carcinogen found in tobacco smoke, for at least 3 months to mimic the behavior of chronic smokers with NSCLC [12, 17]

Nicotine poisoning can make it difficult to clearly distinguish colours with a red or green hue

Smoking is, of course, a nasty and at times fatal habit, but Aidans manner of encouraging Carrie to quit has since come under scrutiny

With the extra foot of width, the boat was now much more stable and could be driven with confidence in tough conditions