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Its use has been documented as early as the 1400s and remnants of coca leaves have been found in the remains of Peruvian mummies

Two other studies that examined similar non-nicotine e-cigarette comparisons ( n = 249 and n = 140) were of very low certainty.29 , 30 Overall, RCTs27 29 , 31 39 examining benefits for smoking cessation of e-cigarettes suggested that e-cigarettes with nicotine may provide a small to moderate cessation benefit at 6 months follow-up compared with non-nicotine e-cigarettes or no intervention, with behavioural support or NRT access provided in both groups.23 Non-nicotine e-cigarette use may result in a small cessation benefit (Appendix 1).23 There were minor differences in study inclusion criteria and the meta-analyses undertaken between our review and the Cochrane living systematic review on e-cigarettes, likely because our review was focused on primary care settings

Current tobacco use Model 2 in Table 2 displays the odds ratios, confidence intervals, and p-values for the associations of each factor with current use of tobacco for both Black and White participants

The tobacco is still there adding a sweet, aromatic sensation but the cumin is very pronounced