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Hence, mitophagy is involved in the self-renewal and differentiation of iPSCs and ESCs, and the dysfunction of mitophagy contributes to the production of mitochondrial ROS

Moreover, SMG secretory cells produce a MUC5B -dominated mucus that requires less post-translational processing and glycosylation than surface epithelial mucus production, consistent with recent studies finding that mucus produced from the SMGs has distinct physical properties from that of surface epithelia 36,37