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While cigarette consumption declined 33% from 2000 to 2011 here in the U.S., the use of other types of tobacco grew by 125%, as smokers sought lower-cost alternatives to cigarettes, whose prices have risen sharply as a growing number of states raise taxes on the product

JAK/STAT [edit] Cigarette contents also modulate multiple STAT proteins activities

FDA regulations Another hit to the industry are new FDA regulations