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Historically, researchers used the change in estimate method to identify confounders by observing how the effect size of an exposure changes when potential confounders are adjusted for in the analysis

(For example, both the infection causing a sore throat and a reaction to medication can cause nausea.) How to Prevent Sore Throat Avoiding close contact with ill people can help a person from getting a throat infection

27 Third, interspecies differences in immune regulation, particularly between mouse and human GPR15 signaling networks, present challenges for the direct translation of these experimental findings into clinical practice