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The functional activity of LAG-3 depends on dynamic protein dimerization, which influences both ligand binding and association with the TCR ( Clinical evidence indicates that LAG-3 receptor blockers have a favorable efficacy and safety profile and may offer therapeutic benefit to patients who have exhausted currently available options for histologically confirmed, locally advanced, unresectable, or metastatic solid tumors, particularly when combined with drugs targeting the PD-1 receptor
Jorddy N Cruz 1* , Mozaniel S Oliveira 2 , Joo H Vogado 3 , Sebastio G Silva 2 , Wanessa A Costa 2 , Fernanda WF Bezerra 2 , Renato A Costa 4 , Raul NC Junior 2 and Antonio MJC Neto 5 1 Faculty of pharmaceutical sciences, Laboratory of Preparation and Computation of Nanomaterials, University of the Amazon, Belm, Brazil 2 Faculty of food engineering, Federal University of Para, Belm, Brazil 3 Faculty of pharmaceutical sciences, Avenida Alcindo Cacela, University of the Amazon, Belm, Brazil 4 Faculty of chemistry, Federal University of Para, Belm, Brazil 5 Laboratory of preparation and computation of nanomaterials, Avenida Alcindo Cacela, University of the Amazon, Belm , Brazil * Corresponding Author(s): Jorddy N Cruz Faculty Of Pharmaceutical Sciences, Laboratory Of Preparation And Computation Of Nanomaterials, University Of The Amazon, Belm, Brazil Tel: +55 66065219, Email: [email protected] Received Date : May 14, 2018 Accepted Date : Aug 06, 2018 Published Date : Aug 21, 2018 Abstract In this work we have studied the molecular interactions of N'-Nitrosoanabasine (NAB) and N'-Nitrosoanatabine (NAT) with CYP2A13 by means of molecular docking simulations
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