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NICOTINE INHALER: SUMMARY Wellbutrin 150mg SR Can use 100mg Non-nicotine cessation aid Sustained-release antidepressant Oral formulation BUPROPION SR BUPROPION:MECHANISM of ACTION Atypical antidepressant thought to affect levels of various brain neurotransmitters - Dopamine - Norepinephrine Clinical effects - craving for cigarettes - symptoms of nicotine withdrawal BUPROPION:CONTRAINDICATIONS Patients with a seizure disorder Patients taking - Wellbutrin, Wellbutrin SR, Wellbutrin XL - MAO inhibitors in preceding 14 days Patients with a current or prior diagnosis of anorexia or bulimia nervosa Patients undergoing abrupt discontinuation of alcohol or sedatives (including benzodiazepines) BUPROPION:WARNINGS and PRECAUTIONS Bupropion should be used with extreme caution in the following populations: - Patients with a history of seizure - Patients with a history of cranial trauma - Patients taking medications that lower the seizure threshold antipsychotics, antidepressants, theophylline, systemic steroids) - Patients with severe hepatic cirrhosis Category C drug Use only if clearly indicated Attempt nondrug treatment first BUPROPION:USE in PREGNANCY BUPROPION SR: DOSING Patients should begin therapy 1 to 2 weeks PRIOR to their quit date to ensure that therapeutic plasma levels of the drug are achieved

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