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In 2021, the FTC reported a sale of 190.2 billion cigarettes, marking a considerable decline from the 200 billion mark for the first time

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Other examples of synergistic subsiances include asbestos and cigarette smoking, which together cause nine times Inure lung cancer than would be expected if the effects of the two substances were merely added, and barbiturates and alcohol, which together can cause fatal respiratory depression at dose levels that would not be expected to kill if the two substances acted independently