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the major psychoactive substance in tobacco is Substances and Their Effects Comparative risk assessment of alcohol,

Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach Scientific Reports Tobacco Nicotine Rutgers Addiction Research Center (RARC) MOC 2021: Tobacco Use Disorder Nicotine: From Discovery to Biological Effects

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Expressions of this imbalance can manifest as constant apathy, lack of sexual desire, or excessive search for self-destructive passions

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