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These results strongly correlate with the increased oxidative stress generated in BBB endothelial cultures (see Figure 3A2) and revealing that the highest level of oxidation is in endothelial cells that are exposed to ultralow and NF cigarette smoke extracts

So when you smoke you get less oxygen in your body, and the bit that makes it through can't get to your skin anyway

The implications concerning casual smuggling are not as clear, given the interaction term between percent border population and average tax rate differential