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Roughly 480,000 Americans die each year from tobacco-related illnesses, and more than 16 million Americans live with a smoking-related disease

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As noted here, previous research on the effects of smoking and secondhand smoke have been difficult to interpret due to variables in the socioeconomic status and educational level of participants. Amish subjects make for clearer and easier to interpret results

Again, the same seven explanatory variables were fitted in the full model and the non-significant variables were removed one by one until the minimal model was reached