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FIGURE 1 Data source Exposures: Smoking, alcohol consumption, and coffee consumption Age of initiation smoking, cigarettes per day, smoking cessation, smoking initiation, coffee consumption, and drinks per week were selected as the six exposure variables of substance use relevant to this study ( N = 341,427), cigarettes per day (CPD, N = 337,334), smoking initiation (showing an individual had ever smoked regularly, N = 1,232,091), and smoking cessation ( N = 547,475)
These documents were all marked as confidential, and in some cases, industry executives were explicit that they wanted this memo destroyed [95]. In a 1961 report from Teflons Polychemicals Research and Development department, Dorothy Hood, Chief of Toxicology, evaluated the toxicity of Teflon dispersing agents in rats and found that liver enlargement was recognized as the most sensitive sign of toxicity [89]. It found that Teflon materials had the ability to increase the size of the liver of rats at low doses. The report recommends that all of these materials be handled with extreme care and that contact with the skin should be strictly avoided. In a 1970 internal information request, W.E
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