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It is recommended that new users only use devices with closed systems, such as cartridges and pods, to reduce the risk of poisoning and the addition of other potentially toxic substances to the e-liquid

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In 2019, the FDA authorized the marketing of an earlier version of IQOS, deeming it appropriate for the protection of public health for producing fewer or lower levels of some toxins than combustible cigarettes. In 2020, the agency also granted a supplemental marketing authorization for the IQOS 3 model

When adolescents use non-cigarette tobacco products like hookahs, electronic cigarettes, non-cigarette combustible tobacco, it possibly promotes the smoking of conventional cigarettes says a report