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Some xenobiotics, such as PAHs, produced by tobacco combustion, induce CYP1A1, CYP1A2, CYP1B1, CYP2A8 and UGT genes through transcriptional mechanism

For those with smoking initiation before depression onset, a positive association between the ages at smoking initiation and depression onset was observed, with a younger age at smoking initiation being associated with a younger age at depression onset (Fig