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Excessive oxidative stress may induce oxidative modifications, including peroxidation of mitochondrial lipids, oxidative damage of mitochondrial proteins including OXPHOS components, cristae remodeling, mutations and severe damage in mitochondrial DNA (mtDNA) [5, 6, 22, 39, 40, 42, 43]

A greater number of boys had detectable lead levels in their blood, as did a greater number of Black children and adolescents, compared with the other ethnic groups we studied