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Overall, despite the few above-mentioned reports and the suggestion for a possible association between type V collagen defects and cardiovascular fragility demonstrated in Col5a1 and Col5a2 knock-out mice [124, 125], our results suggest that the risk for severe vascular complications seems to be fairly low in humans harboring a type V collagen defect and the presence of additional, yet unknown, genetic modifiers in families with a severe vascular phenotype is reasonable

Archived from the original on 18 May 2009

Traditional blunts are rolled with tobacco leaf wraps, which means you're introducing nicotine and other byproducts from tobacco combustion

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