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The groups, along with several others, wrote a letter to Zeller at the FDA in early March asking the FDA to revoke its decision on the marketing of the VLN products

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Activated caspase-8 can trigger apoptosis either directly by proteolytically activating the downstream effector caspases, caspases-3, (-6) and -7, however can also proteolytically activate the BH3-only protein BID, thereby increasing effector caspase activation by engaging the intrinsic apoptotic pathway (see above) [10]