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In the aforementioned study exposing human gingival fibroblasts to CS condensate or to nicotine-rich or nicotine-free e-vapour condensates [29], the detrimental effects were greater in cells exposed to nicotine-rich condensate than to nicotine-free condensate, suggesting that the possible injurious effects of nicotine should be considered when purchasing e-refills

Within the limitations of the study, among the tobacco usage patients, males are more prevalent for Recurrent Aphthous Ulcer than females and occurrence of RAU among tobacco users were less.Though there is no association,anti tobacco counselling to be conducted frequently to educate them from harmful effects of tobacco

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