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Despite the obvious biologic plausibility, the lack of consistent epidemiological evidence might be due to methodological issues including lack of cohort follow-up time into older adulthood (when lung cancer usually becomes clinically manifest), small sample sizes, selection and recall biases, and lack of adjustment for tobacco use in the statistical modeling

A monk may actually have been the first to bring it back from Brazil, but Nicot was honored by the botanical name for the species - Nicotiana tabacum

[54] Certain e-liquid flavorings contain diacetyl and acetyl propionyl which give a buttery taste

And then theres the time commitment