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FDA's Pre-Market Tobacco Application requires manufacturers to prove products are 'appropriate for public health protection.' Only 41 products are authorized as of 2025, rationalizing the US market toward compliant major brands

The studys first author, Dr Thivanka Muthumalage says that while the flavoring compounds tested may be safe for ingestion, these results show they are not safe for inhalation

Any tobacco user should have a baseline oral examination and monitor for: Leukoplakia: White patch that does not scrape off Erythroplakia: Red, velvety patch (very high malignant potential) Oral Submucous Fibrosis: Progressive inability to open the mouth, pale mucosa, and a burning sensation to spicy foods "I cannot stress this enough," emphasizes Dr