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Nano Micro perforation or other material including surface treatment , electrostatic nano micro cluster perforation for cigarette, tipping, filter, packaging, plug wrap, Kraft, cement sack, bag, fine and other paper, silicon or other coatings, certain plastic films, laminates, porosity from 80 up to 2500 Coresta Units, from 20 down to 6 Gurley, hole sizes from 50 nm up to 100 microns, hole densities from 80-260 h/cm2, zone widths from 2.0-6.0 mm, up to 16,000,000 holes per Second, web speeds up to 500 m/min, web widths up to 2000 mm

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[149] This suggests that medical use of amphetamine does not significantly affect gene regulation