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58 found that patients with COPD using HTPs experienced fewer COPD exacerbations and significant improvements in symptoms, exercise capacity, and overall health-related quality of life than patients who continued to smoke cigarettes

The median saccharin transit time was almost twice as long in cigarette smokers (13.15 min) compared to never (7.24 min) and former smokers who had abstained for at least 36 months (7.26 min)

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