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Abstract Nicotine, the major component of tobacco smoke (TS) and electronic cigarette (e-cig) vape, has been reported in some cases to be prodromal to cerebrovascular toxicity as well as a promoting factor for the onset of various neurological diseases

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The authors emphasized the importance of collaboration between doctors and industry for continued advances in medicine, but pointed to this study as a reminder to the medical community of the need to adhere to the "highest standards of scientific validity" and to remain vigilant in the advocacy for patients' interests when working with industry

A search of community forums revealed that some vape shops are sending marketing materials to their customers advertising new e-cigarette liquids that contain Nixodine, suggestive of a concerted marketing campaign supporting nicotinamide products 12