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The decline in the numbers caused the tobacco industry to consolidate and they closed many of their manufacturing plants, although tobacco still generates $121 billion annually in the United States

A new product is considered substantially equivalent to an existing product if it has the same characteristics, "characteristics" legally defined as "materials, ingredients, design, composition, heating source, or other features." The law also allows for a finding of substantial equivalence when a product differs in characteristics but raises no new questions of public health

Unregulated liquids may contain harmful substances and have been linked to severe lung injuries