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Fetal Alcohol Syndrome is a very serious health issue for babies whose mothers consumed alcohol during pregnancy, though researchers didnt discover the link between alcohol and adverse infant outcomes until 1968

When smoking duration was used as a continuous measure in place of cigarette pack years in the 3-category age of initiation model (Supplemental Table S3a in the online supplement), the association between childhood smoking and COPD was attenuated (aRR from 1.27 [95% CI=1.06, 1.51] to 1.16 [95% CI=0.99, 1.36])

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It is possible that exposure to tussigenic agents could lead to long or short-term changes in the peripheral sensory nerves or CNS, or for example at the NTS where airway sensory nerves synapse (Bautista et al., 2006)