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However, an American Thoracic Society (ATS) systematic review of eight studies demonstrated that extended use of a controller therapy for greater than 12 weeks leads to significantly higher sustained quit rates and lower relapse rates compared with standard use of six to 12 weeks, with a number needed to treat (NNT) of 19 for one additional patient achieving abstinence at one year

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For example, since bupropion is a weak dopamine uptake inhibitor (Ascher et al., 1995), the efficacy of this product has been attributed to an increase in dopamine levels