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Global Regulatory Landscape Apart from what's happening in the EU, countries all over the world have different ways of regulating nicotine: United States : The FDA is in charge of tobacco products based on the Family Smoking Prevention and Tobacco Control Act

[21] First-generation e-cigarettes tend to look like traditional cigarettes and so are called "cigalikes"

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Our study used devices with known nicotine delivery profiles, which allowed us to effectively compare how the varying levels of nicotine in a device might affect user nicotine dependence and ability to reduce cigarette consumption. The researchers enrolled 520 participants interested in reducing their cigarette intake but with no plans or interest to quit smoking and instructed them to reduce their cigarette consumption over the six-month study period