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Forty-two RCTs that met the PICO-SD criteria were selected from the systematic review.16, 23, 29, 31, 39, 47, 104, 117, 142, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180 The results showed that bupropion significantly increased smoking cessation success rates at six months or longer compared to placebo (RR, 1.57

Up to 68% of smokers successfully quit in 2020-2021 if they combined e-cigarettes with expert input from local Stop Smoking services

CDH1) expression indicating compromised barrier integrity along with heightened cytotoxicity (Fig

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