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While not risk-free, evidence suggests e-cigarettes provide harm reduction

Due to their smaller size and faster burn, cigarillos offer immediate, intense flavors but can lack the evolving complexity found in cigars, which develop gradually with careful tobacco aging

[121], in primary human bronchial epithelial cells, CSE induces EMT partially through the activation of Rac1, PI3K/Akt/-catenin pathways, and the generation of ROS