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These findings in humans may be due to a positive association of green apple based on the individuals history (e.g., positive conditioning with fruit candy consumption as a child) and/or due to biological effects of the chemical on the reward-related neurocircuitry of the brain

Specific CYP450 isoenzymes, such as CYP1A1, 1A2, 1B1, and 2E1, may be implicated (Meech and Mackenzie, 1997)