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I suspect I will be wearing this until the threads finally give out

Finally, one should never forget and consistently communicate that (i) the best choice for a smoker is to quit, (ii) cMRTPs are not risk free, (iii) cMRTPs are addictive as they contain nicotine and, (iv) cMRTPs are not alternatives to quitting

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For example, in terms of binding affinity, THC acts as a partial agonist at both cannabinoid receptors, while CBD exhibits negligible affinity for cannabinoid receptor 1 (CB1) and functions as a partial agonist at cannabinoid receptor 2 (CB2) (Zou and Kumar 2018