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A comprehensive study assessed the cytotoxic impact of IQOS gas phase, particle phase, and whole smoke emissions in comparison to Marlboro Red cigarettes on different types of human pulmonary cells [A549 and BEAS-2B cell lines, normal human bronchial epithelial cell (NHBE) cultures from different donors, normal human lung fibroblasts (NHLF), and human embryonic stem cells)

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Nicotine belongs to a family of compounds called alkaloids and occurs naturally in several varieties of plant, including tomatoes, aubergines and potatoes, but is found at its highest levels in the tobacco plant