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If abrupt discontinuation of clozapine tablets are necessary (because of severe neutropenia or another medical condition, for example) [see Dosage and Administration (2.5), Warnings and Precautions (5.1)] , monitor carefully for the recurrence of psychotic symptoms and adverse reactions related to cholinergic rebound, such as profuse sweating, headache, nausea, vomiting and diarrhea

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2) the independence assumption that the instrumental variables are not associated with any confounders of the exposureoutcome relationship

Plus its reusable, so you can pour it right back in the bottle for the next time you have gunky glass