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E-cig devices have evolved through four generations: from cigarette-like cigalike, to larger and more customizable vape pens/box mods to the recent sleek pod systems like JUUL with high-nicotine salt formulations

Acute and short-to-medium-term exposures were mainly studied by cell/ in vitro and animal studies 18,22,25-29,31,33-37,39-52 , while a single longitudinal study 20 examined long-term exposure

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