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Do not cut patch in half or into smaller pieces

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There is some evidence that the deposition of the particles produced by cigarette smoking is different to that due to biomass or occupational exposures as these are mostly inhaled nasally where the filtration efficiency is higher, whereas tobacco smoke is inhaled through the mouth at a high flow rate leading to greater deposition in the lower airways and alveoli [22]

So when a cigalike was introduced, carrying nicotine inside which can be puffed on using a piece of equipment that bears a canny resemblance to someone who would smoke, well it changed the game